Clinical studies with first generation oncolytic (cancer destroying) viruses are very promising. To ensure this new approach is available to all patients, we develop scalable and robust production methods for these viruses. As part of the Fraunhofer-Gesellschaft, our experts are researching these issues using mathematical methods within the framework of project TheraVision.
When to Infect and When to Extract?
Preparation of the viruses consists of an upstream and a downstream process. Initially, special host cells are grown in the upstream process. At a certain time, these are infected with the virus. From this moment on, the viruses multiply in the host cells until the cells are destroyed and the viruses produced escape into the surrounding nutrient solution. After a certain period of time, the nutrient solution is extracted and fed into the downstream process where the virus is filtered