A variety of obstructive diseases is associated with a loss of lung tissue. In general, the human lung cannot compensate for this loss of tissue. This is different in rodents and smaller animals: E.g., the lung of mice completely regains its original capacity by compensatory growth within 21 days after resection of approximately 40% of the lung tissue. Transferring this behavior to the human lung would greatly improve therapeutic options in many lung diseases.
Microvascular corrosion casts synchrotron-radiation X-ray tomographic images of microvascular corrosion casts. To gain deeper insight into this regeneration process, the topology of the vascular system is studied based on synchrotron-radiation X-ray tomographic images of microvascular corrosion casts. Based on the Euler number, intussusceptive pillars indicating growth can be detected automatically for the first time.