In the project »MaTBiZ«, we combine methods and competences from different research areas. For this reason, three departments of the Fraunhofer ITWM are involved in the project, each contributing their respective expertise:
Example: Filter Media With Foam Structure
In this project, we are looking at foam-like filter media, because of their high connectivity, which makes them highly suitable for 3D printing. In previous work by the department »Image Processing« in collaboration with Prof. Dr. Claudia Redenbach's chair at RPTU Kaiserslautern-Landau, we have so far investigated the modeling of realistic distributions of cell shape and size.
Preliminary Research on the Separation of Cells
If different cell types of a cell culture are to be separated from each other, a selection procedure is required that can distinguish between at least two cell populations. Systems that realize cell separation in flow-through channels simplify the handling and scalability of such separation problems. Here, the department »Flow and Material Simulation« contributes its experience from the project AMSCHA.
Simulation of Flow and Cell Separation
The simulation of flow through porous structures and the adhesion of cells to a functionalized surface can be implemented on different scales and with different methods. Previous research investigating this phenomenon has mostly considered the interaction of a single cell or particle with a (flat) surface. In the BMBF project AMSCHA, we have investigated the adhesion of cells to a functionalized surface in deterministic and stochastic microstructures using simulations. »MaTBiZ« will further build on these findings.
3D Printing Validates Microstructure Simulation
Microstructures that result from numerical optimization can only be additively manufactured in a meaningful way. The additive process must be able to faithfully realize both the relevant pore sizes of less than 100 μm and wall thicknesses in the range of a few μm. The only method that currently meets these criteria is 3D laser lithography using two-photon polymerization. This expertise is contributed by our department »Materials Characterization and Testing«. 3D printing also validates our simulations in the project »ViDestoP« (Virtual Design Chain and Stochastic Prototyping of Nonwovens).